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脂毒性在非酒精性脂肪性肝病发生发展中的作用

张丽慧 刘鸣昊 赵文霞

张丽慧, 刘鸣昊, 赵文霞. 脂毒性在非酒精性脂肪性肝病发生发展中的作用[J]. 临床肝胆病杂志, 2021, 37(2): 463-466. DOI: 10.3969/j.issn.1001-5256.2021.02.045
引用本文: 张丽慧, 刘鸣昊, 赵文霞. 脂毒性在非酒精性脂肪性肝病发生发展中的作用[J]. 临床肝胆病杂志, 2021, 37(2): 463-466. DOI: 10.3969/j.issn.1001-5256.2021.02.045
ZHANG LH, LIU MH, ZHAO WX. Role of lipotoxicity in the development and progression of nonalcoholic fatty liver disease [J]. J Clin Hepatol, 2021, 37(2): 463-466. DOI: 10.3969/j.issn.1001-5256.2021.02.045
Citation: ZHANG LH, LIU MH, ZHAO WX. Role of lipotoxicity in the development and progression of nonalcoholic fatty liver disease [J]. J Clin Hepatol, 2021, 37(2): 463-466. DOI: 10.3969/j.issn.1001-5256.2021.02.045

脂毒性在非酒精性脂肪性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2021.02.045
基金项目: 

河南省科技攻关计划项目 202102310495

河南省中医药科学研究专项 2019JDZX2051

河南省中医药科学研究专项 2018JDZX005

国家自然科学基金 81904154

详细信息
    作者简介:

    张丽慧(1990—),女,主治医师,主要从事中医药防治肝胆疾病研究

    通讯作者:

    赵文霞,zhao-wenxia@163.com

  • 作者贡献声明:张丽慧负责查询文献,撰写论文;刘鸣昊参与修改论文;赵文霞负责指导撰写论文,修改论文并最后定稿。
  • 中图分类号: R575.5

Role of lipotoxicity in the development and progression of nonalcoholic fatty liver disease

  • 摘要: 非酒精性脂肪性肝病(NAFLD)目前是体检时肝脏生化学指标异常的首要原因,但其发生发展的机制仍不十分明确,尚缺乏有效的治疗方法。简述了脂毒性通过触发肝脏内质网应激、细胞死亡、炎症三种病理反应驱动NAFLD向非酒精性脂肪性肝炎、肝硬化的发生及转化,认为脂毒性是促进NAFLD向炎症、纤维化发展的重要因素,为NAFLD的防治提供一种新的途径。
  • 图  1  脂毒性在NAFLD中的作用机制

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  • 收稿日期:  2020-07-29
  • 修回日期:  2020-08-17
  • 刊出日期:  2021-02-20
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