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辅助性T淋巴细胞17/调节性T淋巴细胞比值失衡在HBV相关肝脏疾病进展中的作用

唐光俊 游晶 刘怀鄂 彭玉娟

唐光俊, 游晶, 刘怀鄂, 等. 辅助性T淋巴细胞17/调节性T淋巴细胞比值失衡在HBV相关肝脏疾病进展中的作用[J]. 临床肝胆病杂志, 2021, 37(2): 414-418. DOI: 10.3969/j.issn.1001-5256.2021.02.035
引用本文: 唐光俊, 游晶, 刘怀鄂, 等. 辅助性T淋巴细胞17/调节性T淋巴细胞比值失衡在HBV相关肝脏疾病进展中的作用[J]. 临床肝胆病杂志, 2021, 37(2): 414-418. DOI: 10.3969/j.issn.1001-5256.2021.02.035
TANG GJ, YOU J, LIU HE, et al. Role of T helper 17 cell/regulatory T cell imbalance in the progression of HBV-related liver diseases [J]. J Clin Hepatol, 2021, 37(2): 414-418. DOI: 10.3969/j.issn.1001-5256.2021.02.035
Citation: TANG GJ, YOU J, LIU HE, et al. Role of T helper 17 cell/regulatory T cell imbalance in the progression of HBV-related liver diseases [J]. J Clin Hepatol, 2021, 37(2): 414-418. DOI: 10.3969/j.issn.1001-5256.2021.02.035

辅助性T淋巴细胞17/调节性T淋巴细胞比值失衡在HBV相关肝脏疾病进展中的作用

DOI: 10.3969/j.issn.1001-5256.2021.02.035
基金项目: 

国家自然科学基金 81760111

国家自然科学基金 81760617

云南省应用基础研究项目 2017FE468〔-033〕

详细信息
    作者简介:

    唐光俊(1995—),男,主要从事肝病临床基础研究

    通讯作者:

    游晶,jingyoukm@126.com

  • 作者贡献声明:唐光俊负责文献阅读,撰写论文;刘怀鄂、彭玉娟负责提供意见并修改;游晶负责拟定写作思路,指导撰写文章并最后定稿。
  • 中图分类号: R512.62

Role of T helper 17 cell/regulatory T cell imbalance in the progression of HBV-related liver diseases

  • 摘要: 慢性乙型肝炎患者肝脏损害多发生在免疫介导作用下,考虑病毒感染和免疫反应的相互作用是疾病病情进展的重要原因。慢性乙型肝炎可发展至肝纤维化、肝硬化甚至肝细胞癌。回顾了辅助性T淋巴细胞17(Th17)与调节性T淋巴细胞(Treg)的发现起源,叙述了二者自身特性,同时阐述了在维持免疫系统稳定过程中二者所起的作用及作用机制;详细分析了细胞失衡在慢性乙型肝炎、肝纤维化、肝硬化、肝细胞癌等各个阶段中的作用,指出Th17/Treg失衡会促使HBV相关肝脏疾病病情加重。
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  • 收稿日期:  2020-07-21
  • 修回日期:  2020-09-04
  • 刊出日期:  2021-02-20
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