生物人工肝和肝移植:肝衰竭治疗新模式

丁义涛

doi:10.3969/j.issn.1001-5256.2017.09.013

生物人工肝和肝移植:肝衰竭治疗新模式

DOI: 10.3969/j.issn.1001-5256.2017.09.013

丁义涛

南京大学医学院附属鼓楼医院肝胆外科

详细信息

中图分类号: R657.3
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出版历程
- 收稿日期: 2017-05-22
- 出版日期: 2017-09-20

Bioartificial liver and liver transplantation: new modalities for the treatment of liver failure

Ding YiTao

Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School

摘要

摘要: 肝衰竭的主要特征是肝细胞大范围坏死,病情进展迅速且预后差,目前治疗缺乏特效药物和手段。归纳了肝衰竭的4种治疗手段:内科治疗、细胞移植、肝移植和人工肝支持治疗,并就现有的治疗手段进行阐述分析。目前内科治疗方案有待优化,细胞移植治疗尚未应用于临床,肝移植是最有效的手段,但供肝短缺、费用昂贵,人工肝可以有效清除患者体内毒性物质。因此提出人工肝作为肝移植的过渡治疗,可以为肝再生或者肝移植争取时间,延长患者生存期,具有良好的应用前景。生物人工肝联合肝移植的新模式,可以为肝衰竭患者带来福音。
- 肝功能衰竭 /
- 肝移植 /
- 肝,人工 /
- 治疗
Abstract: The main features of liver failure are extensive necrosis of hepatocytes, rapid disease progression, and poor prognosis, and at present, there are no effective drugs and methods for the treatment of liver failure. This article summarizes four treatment methods for liver failure, i. e., medical treatment, cell transplantation, liver transplantation, and artificial liver support therapy, and elaborates on the existing treatment methods. The current medical treatment regimen should be optimized; cell transplantation has not been used in clinical practice; liver transplantation is the most effective method, but it is limited by donor liver shortage and high costs; artificial liver can effectively remove toxic substances in human body. Therefore, this article puts forward artificial liver as a transition for liver transplantation; artificial liver can buy time for liver regeneration or liver transplantation and prolong patients'survival time and thus has a promising future. The new treatment modality of bioartificial liver combined with liver transplantation may bring good news to patients with liver failure.
- liver failure /
- liver transplantation /
- liver, artificial /
- therapy

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参考文献(38)

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