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PARP-1和caspase-3在胰腺癌及癌旁组织中的表达及意义

蒲竞 李汛 朱骏 白仲天 严峻

蒲竞, 李汛, 朱骏, 白仲天, 严峻. PARP-1和caspase-3在胰腺癌及癌旁组织中的表达及意义[J]. 临床肝胆病杂志, 2016, 32(2): 337-341. DOI: 10.3969/j.issn.1001-5256.2016.02.029
引用本文: 蒲竞, 李汛, 朱骏, 白仲天, 严峻. PARP-1和caspase-3在胰腺癌及癌旁组织中的表达及意义[J]. 临床肝胆病杂志, 2016, 32(2): 337-341. DOI: 10.3969/j.issn.1001-5256.2016.02.029
Pu Jing, Li Xun, Zhu Jun, Bai ZhongTian, Yan Jun. Expression and roles of poly(ADP-ribose) polymerase-1 and caspase-3 in pancreatic cancer and adjacent tissues[J]. J Clin Hepatol, 2016, 32(2): 337-341. DOI: 10.3969/j.issn.1001-5256.2016.02.029
Citation: Pu Jing, Li Xun, Zhu Jun, Bai ZhongTian, Yan Jun. Expression and roles of poly(ADP-ribose) polymerase-1 and caspase-3 in pancreatic cancer and adjacent tissues[J]. J Clin Hepatol, 2016, 32(2): 337-341. DOI: 10.3969/j.issn.1001-5256.2016.02.029

PARP-1和caspase-3在胰腺癌及癌旁组织中的表达及意义

DOI: 10.3969/j.issn.1001-5256.2016.02.029
详细信息
  • 中图分类号: R735.9

Expression and roles of poly(ADP-ribose) polymerase-1 and caspase-3 in pancreatic cancer and adjacent tissues

  • 摘要: 目的探讨聚(腺苷酸二磷酸核糖)聚合酶(PARP)1和半胱氨酸天冬氨酸蛋白酶(caspase)3在胰腺癌及胰腺癌旁组织中的表达。方法收集2013年1月-2014年6月于兰州大学第一附属医院行手术治疗并经术后病理证实为胰腺癌患者的癌组织标本66例及癌旁组织标本113例,行免疫组化检查,分别检测标本中PARP-1及caspase-3的表达。计数资料组间比较采用χ2检验。结果 66例胰腺癌标本中53例有不同程度PARP-1表达,阳性率为80.3%;113例癌旁组织中有39例PARP-1表达,阳性率为34.5%;PARP-1在胰腺癌组织中的阳性表达率明显高于癌旁组织,差异具有统计学意义(χ2=34.79,P<0.01)。在中分化(18/25,72.0%)和低分化(10/14,71.4%)的胰腺癌组织中PARP-1的表达强度明显高于高分化(3/14,21.4%)肿瘤组织,三者间差异具有统计学意义(χ2=10.76,P<0.01)。66例胰腺癌标本中47例有不同程度caspase-3表达,阳性率为71.2%;113例癌旁组织中有71例caspase-3表达,阳性率为62.8%。高分化(1...

     

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  • 收稿日期:  2015-06-04
  • 出版日期:  2016-02-20
  • 刊出日期:  2016-02-20
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