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血清C反应蛋白、脂肪酶、白细胞介素1β和细胞间黏附分子1联合检测在急性胰腺炎诊断中的应用价值

矫树华 刘鹏亮 温艳惠

矫树华, 刘鹏亮, 温艳惠. 血清C反应蛋白、脂肪酶、白细胞介素1β和细胞间黏附分子1联合检测在急性胰腺炎诊断中的应用价值[J]. 临床肝胆病杂志, 2016, 32(1): 131-134. DOI: 10.3969/j.issn.1001-5256.2016.01.025
引用本文: 矫树华, 刘鹏亮, 温艳惠. 血清C反应蛋白、脂肪酶、白细胞介素1β和细胞间黏附分子1联合检测在急性胰腺炎诊断中的应用价值[J]. 临床肝胆病杂志, 2016, 32(1): 131-134. DOI: 10.3969/j.issn.1001-5256.2016.01.025
Jiao ShuHua, Liu PengLiang, Wen YanHui. Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule1 in early identification of severity of acute pancreatitis[J]. J Clin Hepatol, 2016, 32(1): 131-134. DOI: 10.3969/j.issn.1001-5256.2016.01.025
Citation: Jiao ShuHua, Liu PengLiang, Wen YanHui. Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule1 in early identification of severity of acute pancreatitis[J]. J Clin Hepatol, 2016, 32(1): 131-134. DOI: 10.3969/j.issn.1001-5256.2016.01.025

血清C反应蛋白、脂肪酶、白细胞介素1β和细胞间黏附分子1联合检测在急性胰腺炎诊断中的应用价值

DOI: 10.3969/j.issn.1001-5256.2016.01.025
详细信息
  • 中图分类号: R576

Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule1 in early identification of severity of acute pancreatitis

  • 摘要: 目的通过动态检测急性胰腺炎(AP)患者外周血清C反应蛋白(CRP)、脂肪酶(LPS)、白细胞介素(IL)1β和细胞间黏附分子(ICAM)1的水平及变化,评价多种指标联合检测在AP临床诊断中的价值。方法收集2010年1月-2012年12月在中国医科大学附属第四医院进行治疗的AP患者86例,其中重症急性胰腺炎(SAP)患者39例,轻症急性胰腺炎(MAP)患者47例。于入院第1、3、5、7天分别采集患者血清,另选取12例同期健康体检者作为对照。采用ELISA法检测血清中CRP、IL-1β和ICAM-1水平,干片速率法测定血清LPS的浓度。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果 MAP组患者入院第1天的CRP、IL-1β和LPS水平明显高于对照组,差异均有统计学意义(t值分别为-74.126、-60.135、-364.153,P值均<0.001);SAP组患者入院第1天的CRP、ICAM-1、IL-1β、LPS水平均明显高于对照组,差异亦有统计学意义(t值分别为-121.355、-25.728、-89.422、-415.840,P值均<0.001);各检测指...

     

  • [1]Pancreas Study Group,Chinese Society of Gastroenterology,Chinese Medical Association,Editorial Board of Chinese Journal of Pancreatology,Editorial Board of Chinese Journal of Digestion.Chinese guidelines for the management of acute pancreatitis(Shanghai,2013)[J].J Clin Hepatol,2013,29(9):656-660.(in Chinese)中华医学会消化病学分会胰腺疾病学组,《中华胰腺病杂志》编辑委员会,《中华消化杂志》编辑委员会.中国急性胰腺炎诊治指南(2013,上海)[J].临床肝胆病杂志,2013,29(9):656-660.
    [2]INCE AT,BAYSAL B.Pathophysiology,classification and available guidelines of acute pancreatitis[J].Turk J Gastroenterol,2014,25(4):351-357.
    [3]WAN B,FU H,YIN J,XU F.Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis:a randomized controlled trial[J].Scand J Gastroenterol,2014,49(11):1375-1384.
    [4]HUANG Q,LI M,YANG WW,et al.Analysis on the efficacy of low molecular weight heparin in treatment of severe acute pancreatitis[J].J Clin Exp Med,2013,12(18):1459-1461.(in Chinese)黄强,李宓,杨薇薇,等.低分子肝素治疗重症急性胰腺炎的疗效分析[J].临床和实验医学杂志,2013,12(18):1459-1461.
    [5]LI XJ,CHEN YZ,XU LQ.Combined detection of serum amylase and lipase in the diagnosis of acute pancreatitis[J].Int J Lab Med,2011,32(21):2503-2504.(in Chinese)李锡敬,陈艳芝,许柳芹.血清淀粉酶和脂肪酶联合检测在急性胰腺炎诊断中的应用[J].国际检验医学杂志,2011,32(21):2503-2504.
    [6]FENG GM,DU R.Combined dynamic detection of serum lipase and amylase in the diagnosis of acute pancreatitis[J].Med J Chin People's Health,2012,24(9):1038-1040.(in Chinese)丰光明,杜戎.联合动态检测血清脂肪酶和淀粉酶在急性胰腺炎诊断中作用[J].中国民康医学,2012,24(9):1038-1040.
    [7]HOFMEYR S,MEYER C,WARREN BL.Serum lipase should be the laboratory test of choice for suspected acute pancreatitis[J].S Afr J Surg,2014,52(3):72-75.
    [8]VOLZ KA,McG ILLICUDDY DC,HOROWITZ GL,et al.Eliminating amylase testing from the evaluation of pancreatitis in emergency department[J].West J Emerg Med,2010,11(4):344-347.
    [9]KEDIA S,DHINGRA R,GARG PK.Recurrent acute pancreatitis:an approach to diagnosis and management[J].Trop Gastroenterol,2013,34(3):123-135.
    [10]ZHAO H.ICAM-1 and acute pancreatitis[J].Surg Foreign Med Sci,2002,29(6):346-349.(in Chinese)赵华.ICAM-1与急性胰腺炎[J].国外医学:外科学分册,2002,29(6):346-349.
    [11]KAPLAN M,YAZGAN Y,TANOGLU A,et al.Effectiveness of interleukin-1 receptor antagonist(Anakinra)on cerulein-induced experimental acute pancreatitis in rats[J].Scand J Gastroenterol,2014,49(9):1124-1130.
    [12]WANG XY,TANG QQ,ZHANG JL,et al.Effect of SB203580 on pathologic change of pancreatic tissue and expression of TNF-αand IL-1βin rats with severe acute pancreatitis[J].Eur Rev Med Pharmacol Sci,2014,18(3):338-343.
    [13]SHA T,YI JH.The diagnostic value of C-reaction protein in acute pancreatitis[J].Lab Med Clin,2013,10(8):962-964.(in Chinese)沙涛,易金宏.C-反应蛋白对急性胰腺炎的诊断价值[J].检验医学与临床,2013,10(8):962-964.
    [14]CHEN SZ,LI YX,LI J,et al.Evaluation of serum C-reaction protein in acute pancreatitis[J].Mod Med Health,2013,29(18):2799-2801.(in Chinese)陈善正,李宜雄,李窖,等.血清C-反应蛋白在急性胰腺炎病情评估中的意义[J].现代医药卫生,2013,29(18):2799-2801.
    [15]YIN G,HU G,CANG X,et al.C-reactive protein:rethinking its role in evaluating the severity of hyperlipidemic acute pancreatitis[J].Pancreas,2014,43(8):1323-1328.
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  • 收稿日期:  2015-06-01
  • 刊出日期:  2016-01-20
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