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乙型肝炎相关性肝衰竭患者HBV DNA低水平复制及特异性抗体表达的临床意义

田方圆 单静 唐宽银 曹武奎

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乙型肝炎相关性肝衰竭患者HBV DNA低水平复制及特异性抗体表达的临床意义

DOI: 10.3969/j.issn.1001-5256.2014.06.012
详细信息
  • 中图分类号: R512.62;R575.3

Clinical significance of low- level HBV DNA replication and specific antibody expression in patients with HBV- related liver failure

  • 摘要: 目的探讨乙型肝炎相关性肝衰竭患者血清HBV DNA低水平复制及HBV特异性抗体表达的相关因素及临床意义。方法收集2008年6月至2013年12月于天津市第二人民医院住院治疗的391例乙型肝炎相关性肝衰竭患者及394例慢性乙型肝炎患者的病历资料。比较乙型肝炎相关性肝衰竭与慢性乙型肝炎患者HBV DNA表达的不同及影响因素分析。根据HBV血清学标志物(HBV M)特异性表达的不同将肝衰竭患者分为特异性抗体阳性(指抗-HBs、抗-HBe和抗-HBc同时阳性)和特异性抗体阴性(无抗-HBs、抗-HBe和抗-HBc同时阳性)2组,分析2组患者HBV DNA水平的变化和生存情况。组间比较采用独立样本t检验或MannWhitney秩和检验,计数资料比较采用χ2检验。结果乙型肝炎相关性肝衰竭患者HBV DNA水平低于慢性乙型肝炎组,差异有统计学意义(Z=-16.469,P<0.05);HBeAg阳性和阴性的肝衰竭患者HBV DNA水平均低于相应的慢性乙型肝炎患者,差异有统计学意义(Z分别为-11.665和-12.853,P<0.05)。在391肝衰竭病例中,HBV特异性抗体阳性组29例(7...

     

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  • 收稿日期:  2014-01-15
  • 出版日期:  2014-06-20
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