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202例散发性成人急性乙型肝炎患者的流行病学特征和血清学变化

郑冬春 聂苑霞 梁海林 胡岳林 成效 冯晓霞 陈永平

引用本文:
Citation:

202例散发性成人急性乙型肝炎患者的流行病学特征和血清学变化

DOI: 10.3969/j.issn.1001-5256.2014.01.009
详细信息
  • 中图分类号: R512.62

Epidemiological features and serological changes in sporadic acute hepatitis B among adults: an analysis of 202 cases

  • 摘要: 目的了解散发成人急性乙型肝炎(AHB)流行病学特征及其血清病毒标志物(HBV M)演变规律。方法以202例成人AHB患者为研究对象,收集患者流行病学资料并定期随访检测ALT、TBil、HBV DNA、HBV M及其定量,观察其动态变化,随访期为48周。计数资料采用非参数秩和检验,计量资料组间比较采用成组t检验,相关性分析采用Person检验。结果 AHB患者男性明显多于女性,平均(42.99±7.31)岁。微量血传播方式最多,占29.20%,异性性传播占17.33%,但高达48.02%的患者传播途径不明。就诊时仅49.01%的患者HBV DNA阳性。HBV DNA阳性组血清ALT平均值为(1973.2±445.3)U/L;阴性组为(1500.3±287.7)U/L,两者差异无统计学意义(t=1.852,P>0.05);HBV DNA阳性组血清TBil平均值为(118.40±37.33)μmol/L;阴性组为(81.06±23.24)μmol/L,两者差异有统计学意义(t=2.765,P<0.01)。初诊时HBV M呈现8种模式,以HBsAg、HBeAg、抗-HBc、抗-HB...

     

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  • 收稿日期:  2013-06-25
  • 出版日期:  2014-01-20
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