肝硬化食管胃静脉曲张破裂出血的预防和治疗新进展

邵翠萍; 徐小元

肝硬化食管胃静脉曲张破裂出血的预防和治疗新进展

北京大学第一医院感染疾病科

基金项目:

高等学校博士学科点专项科研基金(20090001110081)；国家科技重大专项(2008ZX10002-013)；北京市科委2012年度科技计划重大项目；

详细信息

中图分类号: R575.2
计量
- 文章访问数: 3267
- HTML全文浏览量: 10
- PDF下载量: 841
- 被引次数: 0
出版历程
- 出版日期: 2012-09-20

Progress in the prevention and treatment of bleeding gastroesophageal varices in patients with cirrhosis

Research funding:

摘要

摘要: <正>肝硬化患者门静脉系统血流受阻导致门静脉及其属支血管内静力压力升高并伴侧支循环形成,临床主要表现为腹水、脾大、肝性脑病以及食管胃静脉曲张破裂出血等。其中,食管胃静脉曲张破裂出血的病死率最高,是最常见的消化系统急症之一。
- 肝硬化 /
- 食管和胃静脉曲张
- liver cirrhosis /
- esophageal and gastric varices

HTML全文

参考文献(36)

[1]Garcia-Tsao G, Bosch J.Management of varices and varicealhemorrhage in cirrhosis[J].N Engl J Med, 2010, 362 (9) :823-832.

[2]Burroughs AK, Triantos CK, O’Beirne J, et al.Predictors ofearly rebleeding and mortality after acute variceal hemorrhagein patients with cirrhosis[J].Nat Clin Pract GastroenterolHepatol, 2009, 6 (2) :72-73.

[3]Bátovsky M.Do we need endoscopic sclerotherapy of oeso-phageal varices or the last turn off the light[J].Vnitr Lek, 2011, 57 (12) :989-992.

[4]Garcia-Tsao G, Sanyal AJ, Grace ND, et al.Prevention andmanagement of gastroesophageal variceal and variceal hemor-rhage in cirrhosis[J].Hepatology, 2007, 46 (3) :922-938.

[5]Zhang C, Thabut D, Kamath PS, et al.Oesophageal varicesin cirrhotic patients:from variceal screening to primary proph-ylaxis of the first oesophageal variceal bleeding[J].Liver Int, 2011, 31 (1) :108-119.

[6]Senzolo M, Cholongitas E, Burra P, et al.beta-Blockersprotect against spontaneous bacterial peritonitis in cirrhoticpatients:a meta-analysis[J].Liver Int, 2009, 29 (8) :1189-1193.

[7]Gluud LL, Klingenberg S, Nikolova D, et al.Banding ligationversus betablockers as primary prophylaxis in esophageal var-ices:systematic review of randomized trials[J].Am J Gas-troenterol, 2007, 102 (12) :2842-2848.

[8]Ouakaa-Kchaou A, Kharrat J, Mir K, et al.Variceal bandligation in the prevention of variceal bleeding:a multicentertrial[J].Saudi J Gastroenterol, 2011, 17 (2) :105-109.

[9]Tursi T.Use ofβ-blocker therapy to prevent primary bleed-ing of esophageal varices[J].J Am Acad Nurse Pract, 2010, 22 (12) :640-647.

[10]Yoshida H, Mamada Y, Taniai N, et al.Treatment modalitiesfor bleeding esophagogastric varices[J].J Nihon Med Sch, 2012, 79 (1) :19-30.

[11]Juan Carlos Garcia-Pagan.Acute varicel hemorrhage[C].Cir-rhosis:current challenges and future directions.Sixty-SecondAnnual AASLD, Moscone West San Francisco, California, 4-5November 2001:147-151.

[12]García-Pagán JC, Reverter E, Abraldes JG, et al.Acutevariceal bleeding[J].Semin Respir Crit Care Med, 2012, 33 (1) :46-54.

[13]Sarin SK, Sharma P.Terlipressin:an asset for hepatologists![J].Hepatology, 2011, 54 (2) :724-728.

[14]Azam Z, Hamid S, Jafri W, et al.Short course adjuvant terli-pressin in acute variceal bleeding:A randomized double blinddummy controlled trial[J].J Hepatol, 2012, 56 (4) :819-824.

[15]Vlachogiannakos J, Kougioumtzian A, Triantos C, et al.Clini-cal trial:The effect of somatostatin vs.octreotide in preven-ting post-endoscopic increase in hepatic venous pressuregradient in cirrhotics with bleeding varices[J].Aliment Phar-macol Ther, 2007, 26 (11-12) :1479-1487.

[16]中国医师协会急诊医师分会.急性上消化道出血急诊诊治专家共识[J].中国急救医学, 2010, 30 (4) :289-293.

[17]Sharma P, Sarin SK.Improved survival with the patients withvariceal bleed[J].Int J Hepatol, 2011, 2011:356919.

[18]Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila FI, etal.Antibiotic prophylaxis for cirrhotic patients with upper gastro-intestinal bleeding[J].Cochrane Database Syst Rev, 2010, 8 (9) :CD002907.

[19]Shi D, Wang QZ.Clinical effects of using a reloading multi-band ligator with an SD-c conductor for endoscopicvaricealligation over subsequent sessions[J].Clin Res Hepatol Gas-troenterol, 2012, Mar 14.

[20]de Franchis R, Baveno V Faculty.Revising consensus in por-tal hypertension:report of the Baveno V consensus work-shop on methodology of diagnosis and therapy in portal hy-pertension[J].J Hepatol, 2010, 53 (4) :762-768.

[21]Garcia-Pagán JC, Caca K, Bureau C, et al.An early deci-sion for PTFE-TIPS improves survival in high risk cirrhoticpatients admitted with an acute variceal bleeding:A multi-centric RCT[J].Hepatology, 2008, 48 (Suppl 2) :373A-374A.

[22]Thabut D, Rudler M, Lebrec D.Early TIPS with covered stentsin high-risk patients with cirrhosis presenting with variceal-bleeding:are we ready to dive into the deep end of the pool?[J].J Hepatol, 2011, 55 (5) :1148-1149.

[23]Akahoshi T, Tomikawa M, Kamori M, et al.Impact of bal-loon-occluded retrograde transvenous obliteration on man-agement of isolated fundal gastric variceal bleeding[J].Hep-atol Res, 2012, 42 (4) :385-393.

[24]Dadabhai AS, Fenkel JM, Brown DB, et al.Balloon occlu-ded retrograde transvenous obliteration for the treatment ofgastric varices[J].Hepatology, 2012, 55 (4) :1301-1304.

[25]Augustin S, Millán L, González A, et al.Prognostic evalua-tion of patients with acute variceal bleeding[J].Dis Mark-ers, 2011, 31 (3) :155-164.

[26]Pérez-Ayuso RM, Valderrama S, Espinoza M, et al.Endo-scopic band ligation versus propranolol for the primary proph-ylaxis of variceal bleeding in cirrhotic patients with high risk e-sophageal varices[J].Ann Hepatol, 2010, 9 (1) :15-22.

[27]Burroughs AK, Triantos CK.Predicting failure to control bleedingand mortality in acute variceal bleeding[J].J Hepatol, 2008, 48 (2) :185-188.

[28]La Mura V, Abraldes JG, Raffa S, et al.Prognostic value ofacute hemodynamic response to i.v.propranolol in patientswith cirrhosis and portal hypertension[J].J Hepatol, 2009, 51 (2) :279-287.

[29]Garcia-Pagan JC, Caca K, Bureau C, et al.Early use ofTIPS in patients with cirrhosis and variceal bleeding[J].NEng J Med, 2010, 362 (25) :2370-2379.

[30]Funakoshi N, Ségalas-Largey F, Duny Y, et al.Benefit ofcombinationβ-blocker and endoscopic treatment to preventvariceal rebleeding:a meta-analysis[J].World J Gastroen-terol, 2010, 16 (47) :5982-5992.

[31]González A, Augustin S, Dot J, et al.Adding banding liga-tion is effective as rescue therapy to prevent variceal rebleed-ing in haemodynamic non-responders to pharmacologicaltherapy[J].Dig Liver Dis, 2012, 44 (1) :55-60.

[32]Avgerinos A, Armonis A, Stefanidis G, et al.Sustained riseof portal pressure after sclerotherapy, but not band ligation, in acute variceal bleeding in cirrhosis[J].Hepatology, 2004, 39 (6) :1623-1630.

[33]Thomas D.Boyer.Preventing recurrent variceal hemorrhage[C].Cirrhosis:current challenges and future directions.Sixty-Second Annual AASLD, Moscone West San Francis-co, California, 4-5 November 2011:120-122.

[34]Tripathi D, Hayes PC.The role carvedilol in the managementof portal hypertension[J].Eur J Gastroenterol Hepatol, 2010, 22 (8) :905-911.

[35]Villanueva C, Aracil C, Colomo A, et al.Clinical trial:a ran-domized controlled study on prevention of variceal rebleedingcomparing nadolol+ligation vs.hepatic venous pressure gra-dient-guided pharmacological therapy[J].Aliment Pharma-col Ther, 2009, 29 (4) :397-408.

[36]Augustin S, González A, GenescàJ.Acute esophageal varicealbleeding:Current strategies and new perspectives[J].World JHepatol, 2010, 2 (7) :261-274.

施引文献

资源附件(0)

访问统计