结缔组织生长因子在雌激素信号通路参与肝纤维化发生中的作用

韩聚强; 徐小洁; 叶棋浓

结缔组织生长因子在雌激素信号通路参与肝纤维化发生中的作用

1. 北京军区总医院肝病科
2. 北京生物工程研究所

基金项目:

国家自然科学基金资助项目(30972594)；王宝恩肝纤维化研究基金资助项目(20100025)；

详细信息

中图分类号: R575.2
计量
- 文章访问数: 3348
- HTML全文浏览量: 21
- PDF下载量: 774
- 被引次数: 0
出版历程
- 出版日期: 2012-01-20

Connective tissue growth factor regulates the pathogenesis of hepatic fibrosis through estrogen receptors (ER) signal transduction

Research funding:

摘要

摘要: 临床流行病学资料显示肝纤维的发生存在有显著性别差异。研究证实,雌激素通过雌激素受体信号通路直接参与调控肝纤维化的发生。结缔组织生长因子是一种重要的肝纤维化发生相关细胞生长因子,其可能作为雌激素受体共调节因子,直接调控肝纤维化的发生。
- 肝硬化 /
- 受体,雌激素 /
- 结缔组织生长因子
Abstract: There is significant difference between male and female in the pathogenesis of hepatic fibrosis by many clinical epidemiology's data.It was proved that estrogen played an important role through the signal transduction of estrogen receptors.Connective tissue growth factor (CTGF) was found to be related with liver fibrosis.As an important cofactors of estrogen receptor signaling, CTGF could directly regulate the pathogenesis of liver fibrosis.
- live cirrhosis /
- receptors /
- Estrogen

HTML全文

参考文献(26)

[1]Cheng L, Yang Z, Wang X, et al.Suppression of estrogenreceptor transcriptional activity by connective tissue growthfactor[J].PLoS One, 2011, 6 (5) :e20028.

[2]Baig S.Gender disparity in infections of Hepatitis B virus[J].J Coll Physicians Surg Pak, 2009, 19 (9) :598-600.

[3]Wands J.Hepatocellular Carcinoma and Sex[J].N Engl JMed, 2007, 357 (19) :1974-1976.

[4]Lawrence T, Hagemann T, Balkwill F.Sex, Cytokines, andCancer[J].Science, 2007, 317 (6) :51-52.

[5]吴孟超, 陈汉, 沈峰.原发性肝癌的外科治疗-附5524例报告[J].中华外科杂志, 2001, 39 (1) :25-28.

[6]Shimizu I, Kohno N, Tamaki K, et al.Female hepatology:fa-vorable role of estrogen in chronic liver disease with hepatitisB virus infection[J].World J Gastroenterol, 2007, 13 (32) :4295-4305.

[7]Zarski JP, Marcellin P, Leroy V, et al.Characteristics of pa-tients with chronic hepatitis B in France:predominant fre-quency of HBe antigen negative cases[J].J Hepatol, 2006, 45:355-360.

[8]McMahon BJ.The natural history of chronic hepatitis B virus in-fection[J].Semin Liver Dis, 2004, 24 (Suppl 1) :17-21.

[9]Shimizu I, Mizobuchi Y, Yasuda M, et al.Inhibitory effect ofoestradiol on activation of rat hepatic stellate cells in vivo andin vitro[J].Gut, 1999, 44 (20) :127-136.

[10]Yusuda M, Shimizu I, Shiba M, et al.Suppressive effects ofestradiol on dimethylnitrosamine-induced fibrosis of the liverin rats[J].Hepatology, 1999, 29 (30) :719-727.

[11]Zhou Y, Shimizu I, Lu G, et al.Hepatic stellate cells containthe functional receptorβbut not the estrogen receptorαinmale and female rats[J].Biochem Biophys Res commun, 2001, 286:1059-1065.

[12]McCarty MF, Barroso-Aranda J, Contreras F.Genisteinand phycocyanobilin may prevent hepatic fibrosis by sup-pressing proliferation and activation of hepatic stellate cells[J].Med Hypotheses, 2009, 72 (3) :330-332.

[13]Martini PG, Katzenellenbogen BS.Modulation of estrogenreceptor activity by selective coregulators[J].J Steroid Bio-chem Mol Biol, 2003, 85:117-122.

[14]Govind AP, Thampan RV.Membrane associated estrogenreceptors and related proteins:localization at the plasmamembrane and the endoplasmic reticulum[J].Mol Cell Bio-chem, 2003, 253 (1-2) :233-240.

[15]Wang X, Yang Z, Zhang H, et al.The estrogen receptor-interacting protein HPIP increases estrogen-responsivegene expression through activation of MAPK and AKT[J].Biochim Biophys Acta, 2008, 1783 (6) :1220-1228.

[16]Gressner M, Yagmur E, Lahme B, et al.Connective tissuegrowth factor in serum as a new candidate test for assess-ment of hepatic fibrosis[J].J Clinical Chemistry, 2006, 52 (9) :1815-1817.

[17]Abreu JG, Ketpura NI, Reversade B, et al.Connective-tis-sue growth factor (CTGF) modulates cell signalling by BMPand TGF-β[J].Nat Cell Biol, 2002, 4:599-604.

[18]Gressner OA, Gressner AM.Connective tissue growth fac-tor:a fibrogenic master switch in fibrotic liver diseases[J].Liver Int, 2008, 28 (8) :1065-1079.

[19]Leask A.CCN2:a bona fide target for anti-fibrotic drug inter-vention[J].J Cell Commun Signal, 2011, 5 (2) :131-133.

[20]Urtasun R, Latasa M, Demartis M, et al.Connective tissuegrowth factor autocriny in hepatocellular carcinoma:Onco-genic role and regulation by EGFR/YAP-mediated activation[J].Hepatology, 2011, Jul 28.doi: 10.1002/hep.24587.

[21]韩聚强, 焦园园, 丁丽华, 等.新型雌激素受体β信号通路调节因子的分离及鉴定[J].军事医学科学院院刊, 2006, 30 (6) :513-516.

[22]Tache D, Bogdan F, Pisoschi C, et al.Evidence for the in-volvement of TGF-β1-CTGF axis in liver fibrogenesis sec-ondary to hepatic viral infection[J].Rom J Morphol Embry-ol, 2011, 52 (1 Suppl) :409-412.

[23]Chen L, Charrier AL, Leask A, et al.Ethanol-stimulateddifferentiated functions of human or mouse hepatic stellatecells are mediated by connective tissue growth factor[J].JHepatol, 2011, 55 (2) :399-406.

[24]Choi S, Hwang SB.Modulation of the transforming growthfactor-βsignal transduction pathway by hepatitis C virusnonstructural 5A protein[J].J Biol Chem, 2006, 281 (11) :7468-7478.

[25]Weng HL, Ciuclan L, Liu Y, et al.Profibrogenid transforminggrowth factor-b/Activin receptor-like kinase 5 signaling viaconnetive tissue growth factor expression in hepatocytes[J].Hepatology, 2007, 46:1257-1270.

[26]Ito I, Hanyu A, Wayama M, et al.Estrogen inhibits transfor-ming growth factor beta signaling by promoting Smad2/3 degra-dation[J].J Biol Chem, 2010, 285 (19) :14747-14755.

施引文献

资源附件(0)

访问统计