干细胞移植治疗肝硬化的移植途径及优缺点比较

卢昆云; 杨晋辉

干细胞移植治疗肝硬化的移植途径及优缺点比较

昆明医学院第二附属医院肝胆胰内科云南省肝病研究中心

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中图分类号: R575.2
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出版历程
- 出版日期: 2011-11-20

Comparison of the various approaches of stem cell transplantation in liver cirrhosis

摘要

摘要: 肝硬化是各种慢性肝病的终末期表现,近几年兴起的干细胞移植治疗肝硬化具有操作简单、可重复进行、免疫源性弱、治疗费用低等优点,有望成为一种有广阔应用前景的治疗方法。利用干细胞治疗肝硬化有经外周静脉、门静脉、肝动脉、肝内、腹腔等多种移植途径,但是比较移植途径的实验研究报道较少,不同移植途径的疗效对比尚无定论。本文就干细胞移植治疗肝硬化的移植途径及其优缺点作一综述。
- 肝硬化 /
- 干细胞移植
Abstract: Liver cirrhosis is the end-stage of all sorts of chronic liver disease.The encouraging advances in stem cells have paved the way towards the treatment of the end-stage of the chronic liver disease in recent years, which also expected to be an alternative and prospective way.Stem cell transplantation for cirrhosis is characterized by simple, repeatable, lower immunogen and lower costs.There are some various approaches by stem cell transplantation via the peripheral vein, the portal vein, the hepatic artery, intrahepatic injection, et al.The studies on comparing the experimental research on stem cell transplantation are less, and the therapeutic effects of different transplantation approaches are also uncertain.In this paper, we reviewed the approaches of stem cell transplantation and their advantages and disadvantages in cirrhosis.
- liver cirrhosis /
- stem cells

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参考文献(23)

[1]Ramachandran P, Iredale JP.Reversibility of liver fibrosis[J].Ann Hepatol, 2009, 8 (4) :283-291.

[2]Alison MR, Poulsom R, Jeffery R, et al.Hepatocytes fromnon-hepatic adult stem cells[J].Nature, 2000, 406 (6793) :257.

[3]Cerec V, Glaise D, Garnier D, et al.Transdifferentiation of hep-atocyte-like cells from the human hepatoma cell line throughbipotent progenitor[J].Hepatology, 2007, 45:957-967.

[4]Lu LL, Liu YJ, Yang SG, et al.Isolation and characterizationof human umbilical cord mesenchymal stem cells with hema-topoiesis-supportive function and other potentials[J].Haematologica, 2006, 91 (8) :1017-1026.

[5]Najimi M, Smets F, Sokal E.Hepatocyte transplantation:cur-rent and future developments[J].Current Opinion in OrganTransplantation, 2007, 12 (5) :503-508.

[6]Wang X, Ge S, McNamara G, et al.Albumin-expressing hepa-tocyte-like cells develop in the livers of immune-deficientmice that received transplants of highly purified human hemato-poietic stem cells[J].Blood, 2003, 101 (10) :4201-4208.

[7]王满仓, 商中华, 张孝良等.不同途径移植大鼠骨髓问充质干细胞 (BMscs) 对大鼠肝硬化的治疗作用[J].中国现代医生, 2010, 48 (2) :7-8, 20.

[8]Avital I, Inderbitzin D, Aoki T, et al.Isolation, characteriza-tion, and transplantation of bone marrow-derived hepato-cyte stem cells[J].Biochem Biophys Res Commun, 2001, 288 (1) :156-164.

[9]Najimi M, Sokal E. Update on liver cell transplantation [J]. J Pediatr Gastroenterol Nutr, 2004, 39 (4) : 311 -319.

[10]曹葆强，林继波，钟跃思，等自体骨髓细胞经门静脉移植治疗肝硬化与肝功能不全的临床研究[J]中华普通外科杂志，2007．22 (5) .386-389

[11]Mohamadnejad M, Namiri M, Bagheri M, etal. Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis[J]. World J Gastroenterol, 2007, 13 (24) : 3359-3363.

[12]Pai M, Zacharoulis D, Milicevic MN, et al. Autologous Infusion of Expanded Mobilized Adult Bone Marrow-Derived CD34+Cells Into Patients With Alcoholic Liver Cirrhosis[J].Am J Gastroenterol, 2008, 103 (8) :1952-1958.

[13]Khan AA, Parveen N, Mahaboob VS, et al. Safetyand Efficacy of Autologous Bone Marrow Stem Cell Transplantation Through Hepatic Artery for the Treatment of Chronic Liver Failure : A Preliminary Study[J]. Transplant Proc, 2008, 40 (4) :1140-1144.

[14]刘晓天，崔玲，时利平自体骨髓干细胞移植多支血管介入治疗肝硬化的临床研究[J]中国医疗前沿，201 0，5 (11) ：25-26

[15]陈海鸥，胡小宣，刘洪娟，等脐血干细胞移植治疗肝硬化的疗效观察[J]肝脏，2010，15 (2) ：81-83．

[16]Ruhnke M, Ungefroren H, Nussler A, et al. Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells [J]. Gastroenterology, 2005, 128 (7) : 1774-1786.

[17]Ju S, Teng G J, Lu H, et al. ln vivo MR tracking of mesenchymal stem cells in rat liver after intrasplenic transplantation[J]. Radiology, 2007, 245 (1) : 206-215.

[18]Koenig S, Stoesser C, Krause P, et al. Liver repopulation after hepatocellular transplantation: integration and interaction of transplanted hepatocytes in the host[J]. Cell Transplant, 2005, 14 (1) :31-40.

[19]Strom SC, Chowdhury JR, Fox IJ. Hepatocyte transplantation for the treatment of human disease [J]. Semin Liver Dis, 1999, 19 (1) :39-48.

[20]Aoki T, Jin Z, Nishino N, et al. Intrasplenic transplantation ofencapsulated hepatocytes decreases mortality and improves liver functions in fulminant hepatic failure from 90% partial hepatectomy in rats [J]. Transplantation, 2005, 79 (7) : 783-790.

[21]Demetriou AA, Reisner A, Sanchez J, et al. Transplantation of microcarrier-attached hepatocytes into 90% partially heptectomized rats [J]. Hepatology, 1988, 8 (5) :1006-1009.

[22]Salama H, Zekri AR, Zern M, et al. Autologous hematopoietic stem cell transplantation in 48 patients with end -stage chronic liver diseases[J]. Cell Transplant, 2010, 19 (11) :1475-1486.

[23]Leviear N, Pal M, Habib NA, et al. Long -term clinical reults of autologous infusion of mobilized adult bone marrow derived CD34 + cells in patients with chronic liver disease[J]. Cell Prolif, 2008, 41 (Supp11}: 115-125.

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