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血清内脏脂肪素、脂联素与非酒精性脂肪性肝病临床病理的关系

朱超慧 陈东风 艾正琳 杨丽 闵敏

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血清内脏脂肪素、脂联素与非酒精性脂肪性肝病临床病理的关系

详细信息
  • 中图分类号: R575.5

Relationship between serum visfatin and serum adiponectin level and the pathology of nonalcoholic fatty liver disease

  • 摘要: 目的探讨NAFLD临床病理改变与血清内脏脂肪素(visfatin)、脂联素(adiponectin)水平的相关性。方法取54例患者肝组织标本,根据其病理改变分为正常对照组(Control组)、单纯性脂肪肝组(SS组)、非酒精性脂肪性肝炎(NASH组)。酶联免疫法测定所有患者的血清visfatin、adiponectin水平,并比较各组之间visfatin、adiponectin的差异。结果 54例标本中:Control组23例,SS组11例,NASH组20例。NASH组血清visfatin低于Control组(P=0.012)和SS组(P=0.021);SS组血清visfatin较Control组有降低的趋势;Control组血清adiponectin高于NASH组(P=0.024)和SS组(P=0.039);NASH组较SS组有降低的趋势。结论在NAFLD患者中,随着肝组织脂肪变及炎症的加重,其血清visfatin、adiponectin水平逐渐降低。

     

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  • 出版日期:  2011-07-20
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