Abstract: Objective To observe clinic effect of Bifidobiogen-Livzon and Mosapride on patients with liver failure.Methods 42 cases with subacute liver failure, who were admitted to our hospital from January of 2003 to December of 2007, were randomly divided into two groups (treatment group and control group) .The control group was only treated with comprehensive treatment for one month.While for the treatment, besides the comprehensive treatment, Bifidobiogen-Livzon and Mosapride orally were added at the same time.Results The clinic effect of treatment group was significantly prior to control group (P<0.01) .The incidence of complication in treatment group, such as hemorrhage, infection, hepatic encephalopathy, hepatorenal syndrome, was significantly lower than that in control group.Conclusion The curative effect with Bifidobiogen-Livzon and Mosapride on subacute liver failure is significant.