抗双链DNA抗体阳性肝功能异常患者临床及生化特征

赵艳; 闫惠平; 谭玉芬; 刘妍; 马冬梅; 冯霞; 李伟华

抗双链DNA抗体阳性肝功能异常患者临床及生化特征

基金项目:

国家自然基金(30570723)；北京市自然基金(7062033)；

详细信息

中图分类号: R575
计量
- 文章访问数: 3079
- HTML全文浏览量: 18
- PDF下载量: 1364
- 被引次数: 0
出版历程
- 出版日期: 2008-01-20

Clinical and laboratory characters of the liver dysfunctional patients with antibodies to double-stranded DNA.

Research funding:

摘要

摘要: 目的探讨抗双链DNA抗体阳性肝功异常患者的临床及生化特征。方法收集肝功异常患者血清884例,采用免疫印迹法检测抗双链DNA抗体。结果抗双链DNA抗体阳性患者16例（1.81%）,女性患者14例,男性2例;平均年龄（48.94±17.57）岁（9岁69岁）。其中自身免疫性肝炎13例（81.25%）。16例抗双链DNA阳性患者中肝硬化8例（50%）,亚急型重型肝炎2例,急性重型肝炎1例。ALT平均值为（433.91±405.86）U/L,AST平均值为（535.05±513.92）U/L,TBil平均值（182.46±149.11）μmol/L,DB+il平均值为（118.33±103.97）μmol/L,PTA平均值为（75.27±31.22）%,IgG平均值（23.48±13.26）g/L。16例患者ANA抗体均阳性,并伴有多种自身抗体。结论在抗双链DNA抗体阳性的肝功异常患者中AIH发病率较高,且病情较重。对抗双链DNA抗体阳性的肝功异常患者临床应予以重视。
- 自身抗体 /
- 抗双链DNA抗体 /
- 自身免疫性肝炎 /
- 肝硬化
Abstract: Objective To study the clinical and laboratory features of liver dysfunctional patients with antibodies to double-stranded DNA.Methods From July 2005-July 2006, 884 serum samples from patients with abnormal liver function were collected.Antibodies to double-stranded DNA were detected.Results Among the 884 serum samples, 16 (1.81%) cases with positive anti-dsDNA were found including 14 females and 2 males.The average age was (48.94±17.57) years old (range from 9 to 69 years old) .Of 16 caes, 8 cases (50%) were diagnosed liver cirrhosis, 2cases were diagnosed subacute serious hepatitis and 1case was acute serious hepatitis.The average ALT was (433.91±405.86) U/L, The average AST was (535.05±513.92) U/L.The average TBil was (182.46±149.11) umol/L, The average DBil was (118.33±103.97) umol/L.The average IgG was (23.48±13.26) g/L.16 cases were all positive ANA and associate multi-auto antibodies.Conclusion The AIH frequency is very high in the abnormal liver function with anti-dsDNA, and stage of anti-dsDNA positive patients with liver dysfunction are generally serious.The patients should be paid more attention by medical staffs.
- autoantibody /
- antibodies to double-stranded DNA /
- autoimmune hepatitis /
- liver cirrhosis

HTML全文

参考文献(6)

[1]Alvarez F, Berg PA, Bianchi FB, et al.International AutoimmuneHepatitis Group Report:reviewof criteria for diagnosis of autoimmunehepatitis[J].Hepatol, 1999, 31∶929-938.

[2]中华医学会.慢性乙型肝炎防治指南[J].中华肝脏病杂志, 2005, 13 (12) ∶881-891.

[3]熊华, 李晓军, 齐名.质粒抗原酶联免疫吸附试验检测抗双链抗体的研究[J].中华检验医学杂志, 2003, 26∶374-376.

[4]Tsuchiya K, Kiyosawa K, Imai H, et al.D etection of anti-doubleand-single stranded DNAantibodies in chronic liver disease:signif-icance of anti-doule stranded DNA antibodies in autoimmune hepa-titis[J].J Gastroentol, 1994, 29∶152-158.

[5]Czaja, AJ, Morshed SA, Parveen S, et al.Antibodies to Single-Stranded and Double-Stranded DNAin Antinuclear Antibody-Pos-itive Type 1-Autoim mune Hepatitis[J].Hepatology, 1997, 26 (3) ∶568-572.

[6]Ohnishi K, Ebling FM, Mitchell B, et al.Comparison of pathogenicand non-pathogenic murine antibodies to DNA:antigen binding andstructural characteristics[J].Int Immunol, 994, 6∶817-830.

施引文献

资源附件(0)

访问统计