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The relationship between transforming growth factor β1 and liver fibrosis
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摘要: 研究转化生长因子 β1（TGFβ1）与病毒性肝炎肝纤维化的关系。对 45例慢性病毒性肝炎病人肝组织进行了TGFβ1免疫组织化学检测 ,同时检测其中 2 1例血清TGFβ1及血清透明质酸 （HA）、层粘蛋白 （LN）、Ⅳ型胶原 （Ⅳ -C）、Ⅲ型前胶原肽 （PⅢP）水平。结果 :随着肝纤维化程度加重 ,TGFβ1血清水平上升 ,肝内表达逐渐明显 ,二者呈正相关 ;TGFβ1的血清水平及肝内表达与HA、LN、Ⅳ -C、PⅢP四项肝纤维化指标均呈正相关关系。TGFβ1通过活化肝脏间质细胞 ,促进肝脏基质合成加速肝纤维化发展。Abstract: WT5”BZ] To study the relationship between transforming growth factor β 1 (TGFβ 1) and liver fibrosis.The expression of TGFβ 1 protein in liver tissues were detected by immunohistochemical methods in 45 cases with viral hepatitis and cirrhosis, and the serum level of TGFβ 1, hyaluronic acid (HA) , laminin (LN) , collagen type Ⅳ (Ⅳ-C) and precollagen type Ⅲ (PⅢP) were measured in 21 of these 45 cases.Results:The serum level of TGFβ 1 and its expression in liver tissues were positively correlated.Both of them were positively correlated with the degree of liver fibrosis and serum level of HA, LN, Ⅳ, PⅢP.Conclusion:TGFβ 1 could accelarate the process of liver fibrosis by increasing synthesis of extracellular matrix components.
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[1]病毒性肝炎防治方案 (试行 ) 。中华传染病杂志 , 1995 , 13∶2 41 [][2 ]LawranceDA .TGFβ :anoverview .KidneyInt , 1995 , 47∶S19 [][3 ]NagyP , SchaffZ , LapisK .ImmunohistochemicaldetectionofTGFβ1 infibroticliverdiseases.Hepatology , 1991, 14∶2 19 [4]BedossaP , PeltierE , TerrisB , etal.TGFβandTGFβreceptorsinnormal, cirrhoticandneoplastichumanlivers.Hepatology , 1995 , 2 1∶760 [][5 ]孙自勤 , 王要军 , 全启镇 .血清PⅢP、PCⅢ、HA、LN和PE测定在实验性肝纤维化诊断与疗效考核中的意义。实用肝脏病杂志。1996, 1∶74 -
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