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The role of autophagy in the development and progression of acute pancreatitis
文章发布日期:2019年04月04日  来源:  作者:李春云,刘瑞霞,阴赪宏,等  点击次数:646次  下载次数:169次
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【Abstract】:Acute pancreatitis (AP) is an exocrine inflammatory disease of the pancreas, the pathophysiological mechanism of AP remains unclear. Autophagy is an important pathway of metabolic degradation in cells, and autophagy impairment is closely associated with the development and progression of many diseases. Recent studies have found that the process of autophagy is abnormal in AP, with impaired fusion of autophagosome and lysosome and a significant reduction in the degradation function of autolysosome. Abnormal activation of pancreatic enzymes and inflammatory response is the key event in the initiation of AP, and abnormal autophagy is closely associated with these two events. The study of the upstream and downstream mechanisms of autophagy dysfunction in AP may help to find new molecular targets and strategies for the treatment of AP.
【Key words】:pancreatitis; autophagy; tysosome-associated membrane glycoproteins; inflammation; review

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