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You are here:Home => Online Journal => Vol.35 No.5,2019 Multidisciplinary diagnosis and treatment of pancreatic cancer => Reviews =>
Role and mechanism of autophagy in development and progression of hepatocellular carcinoma and regulation of immunotherapy
文章发布日期:2019年04月04日  来源:  作者:王沐淇,李亚萍,刘拉羊,等  点击次数:555次  下载次数:206次
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【Abstract】:As a basic physiological phenomenon, autophagy plays an important role in maintaining cellular homeostasis and physiological metabolism and can also induce programmed cell death. At present, many studies have shown that autophagy plays an important role in the development, progression, and metastasis of various tumors, which provide new viewpoints for tumor research and treatment. Hepatocellular carcinoma has an extremely complex pathogenesis, and the effect of immunoregulation on the development, metastasis, and invasion of hepatocellular carcinoma has been generally accepted. Recent studies have found that autophagy is involved in tumor immunity, oxidative stress, and maintenance of cellular homeostasis and thus affect the progression of hepatocellular carcinoma. It may also influence the effect of immunotherapy via multiple pathways. This article reviews the role and mechanism of autophagy in the development and progression of hepatocellular carcinoma and the regulation of immunotherapy, in order to understand the significant influence of autophagy on hepatocellular carcinoma and the potential therapeutic value of autophagy.
【Key words】:carcinoma, hepatocellular; autophagy; immunotherapy; review

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