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Studies on relevant gactors of Child-Pugh grading in hepatic cirrhosis
文章发布日期:2011年03月15日  来源:  作者:袁继丽 刘成海 赵长青  点击次数:8447次  下载次数:1653次
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【Abstract】:Objective To investigate the correlation of Cholinesterase (ChE), prothrombin time (PT), Serum Cystatin C (CysC ), serum creatinine (Cr), blood urea nitrogen (BUN), serum calcium (Ca2+) and serum phosphorus (P) with different Child-Pugh classification in hepatic cirrhosis patients. Methods In 179 hepatic cirrhosis patients with different Child-Pugh classification, serum ChE, PT, CysC, Cr, BUN, Ca2+ and P were retrospectively analyzed. And their clinical significance was appraised with Pearson correlation analysis and Multinomial logistic regression analysis. Results erum ChE and Ca2+remarkablely declined and PT increased with increases grading of Child-pugh classification (P<0.05); CysC and Cr increased gradually having a significant difference between Child A group vs Child C group (P<0.05); Bun increased gradually with a significant difference between the two groups Child A group vs Child C group and Child B group vs Child C group (P<0.05). There was no difference in P in all groups. Pearson correlation analysis showed that age, PT, BUN and Cr were positively correlated with Child-Pugh grading, and that ChE was negatively correlated with it. Multinomial logistic regression analysis showed that factors influencing Child-Pugh included CHE and PT. Conclusions Serum ChE, CysC, BUN, Cr and Ca2+ changed with different Child-Pugh classification. Serum ChE had important guiding value on the clinical assessment of liver diseaseseverity.
【Key words】:liver cirrhosis; cholinesterases; cysteine proteinase inhibitors

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