Home   About the Journal  Editorial Board  Online Journal   Publishing Ethics   Contact Us  Chinese Version
You are here:Home => Online Journal => Vol.36 No.11 => Editorial =>
Emphasis on the basic and clinical research on hepatorenal syndrome
文章发布日期:2020年10月22日  来源:  作者:李妍,陆伦根  点击次数:4521次  下载次数:142次
Adjust font size:Small regular big

【Abstract】:Hepatorenal syndrome (HRS) is one of the most severe complications of decompensated cirrhosis. Splanchnic arterial vasodilation in patients with advanced liver cirrhosis and the reduction in cardiac output due to cirrhotic cardiomyopathy may trigger the reduction in effective circulating blood volume, the activation of endogenous vasoconstrictor systems, and significant contraction of renal blood vessels; meanwhile, impairment in renal autoregulation of blood flow may finally lead to the reductions in renal blood flow and glomerular filtration rate. Systemic inflammation also plays an important role in the pathogenesis of HRS. The treatment of HRS should start as soon as it is diagnosed. In the past, HRS was considered “functional” renal insufficiency, while at present, it is considered a spectrum of diseases gradually changing from functional renal insufficiency to varying degrees of parenchymal damage. As there are still no suitable animal models of HRS, current investigations of the pathophysiology of HRS and related pharmacological research mainly rely on clinical studies, which brings difficulties in further understanding the natural history and pathophysiology of HRS. This article reviews the recent advances in the basic and clinical research on HRS and related difficulties.
【Key words】:hepatorenal syndrome; systemic inflammatory response syndrome; adrenal insufficiency; therapeutics

Mail address: Editorial Office of Journal of Clinical Hepatology, 519 Dongminzhu Street, Changchun, Jilin, China Postal code: 130061 Tel:+86-431-88782542/3542
Journal of Clinical Hepatology Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号